South Park is not eligible as it started airing in 1997.

given this is Henry: (https://bindingofisaacrebirth.fandom.com/wiki/Henry)

is Isaac crying because of constipation?

Huh I had no idea, certainly looks bad tho, I retract my statement.

A publisher has creative control over the games, and can make you make changes for profitability and veto creatively risky games. There are definitely good publishers out there (e.g Annapurna the publisher of outerwilds seems pretty chill), this meme is about AAA studios and how the massive studios have all gone to shit.